AustralieFrV1, Main, Exploration, bibRecord, 005085

Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

Identifieur interne : 005085 ( Main/Exploration ); précédent : 005084; suivant : 005086

Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

Auteurs : Gene Colice [États-Unis] ; Richard J. Martin [États-Unis] ; Elliot Israel [États-Unis] ; Nicolas Roche [France] ; Neil Barnes [Royaume-Uni] ; Anne Burden [Royaume-Uni] ; Peter Polos [États-Unis] ; Paul Dorinsky [Australie] ; Elizabeth V. Hillyer [Royaume-Uni] ; Amanda J. Lee [Royaume-Uni] ; Alison Chisholm [Royaume-Uni] ; Julie Von Ziegenweidt [Royaume-Uni] ; Francesca Barion [Royaume-Uni] ; David Price [Royaume-Uni]

Source :

Journal of allergy and clinical immunology [ 0091-6749 ] ; 2013.

RBID : Pascal:13-0240272

Descripteurs français

Pascal (Inist)
- Asthme, Pronostic, Evolution, Béclométasone, Coût, Economie santé, Fluticasone, Aspect économique, Traitement, Immunologie, Immunopathologie.
Wicri :
- topic : Immunologie.

English descriptors

KwdEn :
- Asthma, Beclometasone, Costs, Economic aspect, Evolution, Fluticasone, Health economy, Immunology, Immunopathology, Prognosis, Treatment.

Abstract

Background: Characteristics of inhaled corticosteroids (ICSs) differ, but data comparing the real-life effectiveness of various ICSs for asthma are lacking. Objective: We sought to compare real-life asthma outcomes and costs of extrafine hydrofluoroalkane (HFA)-beclomethasone and fluticasone administered through a pressurized metered-dose inhaler. Methods: This retrospective matched cohort study examined database markers of asthma control from a large US longitudinal health care claims database over 1 baseline and 1 outcome year for 10,312 patients with asthma aged 12 to 80 years receiving their first ICS as HFA-beclomethasone or fluticasone and matched on baseline demographic characteristics and asthma severity. Results: Patients started on HFA-beclomethasone had significantly higher odds (adjusted odds ratio, 1.19; 95% CI; 1.08-1.31) of achieving overall control (risk and impairment), which was defined as no hospital attendance for asthma, oral corticosteroids, or antibiotics for lower respiratory tract infection and less than 2 puffs per day of short-acting β-agonist; they also experienced a lower rate of respiratory-related hospitalizations or referrals (adjusted rate ratio, 0.82; 95% CI, 0.73-0.93) than patients started on fluticasone. Other database outcome measures were similar in the 2 cohorts. Prescribed HFA-beclomethasone doses were lower (P < .001) than fluticasone doses (median, 320 μg/d [interquartile range, 160-320 μg/d] vs 440 μg/d [interquartile range, 176-440 μg/d]). Adjusted respiratory-related health care costs were significantly lower for HFA-beclomethasone than fluticasone (mean, $1869 [95% CI, $1727-$2032] vs $2259 [95% CI, $2111-$2404]), representing a mean annual savings of $390 (95% CI, $165-$620) per patient prescribed HFA-beclomethasone rather than fluticasone. Conclusions: Asthma treatment outcomes were similar or better with HFA-beclomethasone prescribed at significantly lower doses and with lower costs than fluticasone.

Affiliations:

Australie, France, Royaume-Uni, États-Unis
Massachusetts, Île-de-France
Boston, Paris

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000939
to stream PascalFrancis, to step Curation: 005537
to stream PascalFrancis, to step Checkpoint: 000A96
to stream Main, to step Merge: 005270
to stream Main, to step Curation: 005085

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Characteristics of inhaled corticosteroids (ICSs) differ, but data comparing the real-life effectiveness of various ICSs for asthma are lacking. Objective: We sought to compare real-life asthma outcomes and costs of extrafine hydrofluoroalkane (HFA)-beclomethasone and fluticasone administered through a pressurized metered-dose inhaler. Methods: This retrospective matched cohort study examined database markers of asthma control from a large US longitudinal health care claims database over 1 baseline and 1 outcome year for 10,312 patients with asthma aged 12 to 80 years receiving their first ICS as HFA-beclomethasone or fluticasone and matched on baseline demographic characteristics and asthma severity. Results: Patients started on HFA-beclomethasone had significantly higher odds (adjusted odds ratio, 1.19; 95% CI; 1.08-1.31) of achieving overall control (risk and impairment), which was defined as no hospital attendance for asthma, oral corticosteroids, or antibiotics for lower respiratory tract infection and less than 2 puffs per day of short-acting β-agonist; they also experienced a lower rate of respiratory-related hospitalizations or referrals (adjusted rate ratio, 0.82; 95% CI, 0.73-0.93) than patients started on fluticasone. Other database outcome measures were similar in the 2 cohorts. Prescribed HFA-beclomethasone doses were lower (P < .001) than fluticasone doses (median, 320 μg/d [interquartile range, 160-320 μg/d] vs 440 μg/d [interquartile range, 176-440 μg/d]). Adjusted respiratory-related health care costs were significantly lower for HFA-beclomethasone than fluticasone (mean, $1869 [95% CI, $1727-$2032] vs $2259 [95% CI, $2111-$2404]), representing a mean annual savings of $390 (95% CI, $165-$620) per patient prescribed HFA-beclomethasone rather than fluticasone. Conclusions: Asthma treatment outcomes were similar or better with HFA-beclomethasone prescribed at significantly lower doses and with lower costs than fluticasone.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Île-de-France</li>
</region>
<settlement><li>Boston</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Colice, Gene" sort="Colice, Gene" uniqKey="Colice G" first="Gene" last="Colice">Gene Colice</name>
</noRegion>
<name sortKey="Israel, Elliot" sort="Israel, Elliot" uniqKey="Israel E" first="Elliot" last="Israel">Elliot Israel</name>
<name sortKey="Martin, Richard J" sort="Martin, Richard J" uniqKey="Martin R" first="Richard J." last="Martin">Richard J. Martin</name>
<name sortKey="Polos, Peter" sort="Polos, Peter" uniqKey="Polos P" first="Peter" last="Polos">Peter Polos</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Roche, Nicolas" sort="Roche, Nicolas" uniqKey="Roche N" first="Nicolas" last="Roche">Nicolas Roche</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Barnes, Neil" sort="Barnes, Neil" uniqKey="Barnes N" first="Neil" last="Barnes">Neil Barnes</name>
</noRegion>
<name sortKey="Barion, Francesca" sort="Barion, Francesca" uniqKey="Barion F" first="Francesca" last="Barion">Francesca Barion</name>
<name sortKey="Burden, Anne" sort="Burden, Anne" uniqKey="Burden A" first="Anne" last="Burden">Anne Burden</name>
<name sortKey="Chisholm, Alison" sort="Chisholm, Alison" uniqKey="Chisholm A" first="Alison" last="Chisholm">Alison Chisholm</name>
<name sortKey="Hillyer, Elizabeth V" sort="Hillyer, Elizabeth V" uniqKey="Hillyer E" first="Elizabeth V." last="Hillyer">Elizabeth V. Hillyer</name>
<name sortKey="Lee, Amanda J" sort="Lee, Amanda J" uniqKey="Lee A" first="Amanda J." last="Lee">Amanda J. Lee</name>
<name sortKey="Price, David" sort="Price, David" uniqKey="Price D" first="David" last="Price">David Price</name>
<name sortKey="Price, David" sort="Price, David" uniqKey="Price D" first="David" last="Price">David Price</name>
<name sortKey="Von Ziegenweidt, Julie" sort="Von Ziegenweidt, Julie" uniqKey="Von Ziegenweidt J" first="Julie" last="Von Ziegenweidt">Julie Von Ziegenweidt</name>
</country>
<country name="Australie"><noRegion><name sortKey="Dorinsky, Paul" sort="Dorinsky, Paul" uniqKey="Dorinsky P" first="Paul" last="Dorinsky">Paul Dorinsky</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

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